In vitro inhibition of Toxoplasma gondii by four new derivatives of artemisinin.
نویسندگان
چکیده
Toxoplasmosis, caused by the protozoan Toxoplasma gondii, is medically important and distributed worldwide. Currently available medications are limited in terms of efficacy and side effects. We synthesized novel, nonacetal, hydrolytically stable derivatives of artemisinin and showed that they inhibit the replication of Toxoplasma gondii in cell culture.
منابع مشابه
Artemisinin derivatives inhibit Toxoplasma gondii in vitro at multiple steps in the lytic cycle.
OBJECTIVES We sought to improve upon the usefulness of artemisinins as anti-Toxoplasma agents by synthesizing new unsaturated, carba derivatives and then testing them for in vitro efficacy against three steps of the lytic cycle of Toxoplasma gondii tachyzoites. METHODS Novel derivatives of ART were synthesized and then tested for in vitro antiparasitic activity using T. gondii tachyzoites con...
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 50 12 شماره
صفحات -
تاریخ انتشار 2006